Genetic diversity of early (1998) and recent (2010) avian influenza H9N2 virus strains isolated from poultry in Iran
Identifieur interne : 000948 ( Main/Exploration ); précédent : 000947; suivant : 000949Genetic diversity of early (1998) and recent (2010) avian influenza H9N2 virus strains isolated from poultry in Iran
Auteurs : Mohsen Bashashati [Iran] ; Mehdi Vasfi Marandi [Iran] ; Fereshteh Sabouri [Iran]Source :
- Archives of Virology [ 0304-8608 ] ; 2013-10-01.
Abstract
Abstract: Infection with avian influenza H9N2 virus is widespread in the Asian poultry industry, resulting in great economic losses due to mortality and a severe decline in egg production. To obtain more-comprehensive genomic data from circulating H9N2 viruses in Iran, we sequenced the whole genomes of early (Ck/IR/ZMT-101/98) and recent (Ck/IR/EBGV-88/10) isolates of this virus in Iran. The M and NS genes of Ck/IR/EBGV-88/10 shared a high level of similarity with a highly pathogenic H7N3 virus isolated from Pakistan. The cleavage site within the HA protein of these viruses contained two different motifs, RSSR and KSSR, which are similar to those found in low-pathogenic viruses. The deduced amino acid sequence of the new isolate contained the mutation Q226L, which is a characteristic of human-type sialic acid influenza receptor binding. An analysis of the viral amino acid sequence of the M2 protein of the recent strain revealed a V27A mutation, which is associated with amantadine resistance in avian influenza virus. The present results emphasize the need for continuous surveillance of H9N2 viruses in poultry and the human population to obtain more information about the nature and evolution of future pandemic influenza viruses.
Url:
DOI: 10.1007/s00705-013-1699-2
Affiliations:
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Box 14155-6453, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2013-10-01">2013-10-01</date><biblScope unit="volume">158</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="2089">2089</biblScope><biblScope unit="page" to="2100">2100</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Infection with avian influenza H9N2 virus is widespread in the Asian poultry industry, resulting in great economic losses due to mortality and a severe decline in egg production. To obtain more-comprehensive genomic data from circulating H9N2 viruses in Iran, we sequenced the whole genomes of early (Ck/IR/ZMT-101/98) and recent (Ck/IR/EBGV-88/10) isolates of this virus in Iran. The M and NS genes of Ck/IR/EBGV-88/10 shared a high level of similarity with a highly pathogenic H7N3 virus isolated from Pakistan. The cleavage site within the HA protein of these viruses contained two different motifs, RSSR and KSSR, which are similar to those found in low-pathogenic viruses. The deduced amino acid sequence of the new isolate contained the mutation Q226L, which is a characteristic of human-type sialic acid influenza receptor binding. An analysis of the viral amino acid sequence of the M2 protein of the recent strain revealed a V27A mutation, which is associated with amantadine resistance in avian influenza virus. The present results emphasize the need for continuous surveillance of H9N2 viruses in poultry and the human population to obtain more information about the nature and evolution of future pandemic influenza viruses.</div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Bashashati, Mohsen" sort="Bashashati, Mohsen" uniqKey="Bashashati M" first="Mohsen" last="Bashashati">Mohsen Bashashati</name></noRegion><name sortKey="Sabouri, Fereshteh" sort="Sabouri, Fereshteh" uniqKey="Sabouri F" first="Fereshteh" last="Sabouri">Fereshteh Sabouri</name><name sortKey="Vasfi Marandi, Mehdi" sort="Vasfi Marandi, Mehdi" uniqKey="Vasfi Marandi M" first="Mehdi" last="Vasfi Marandi">Mehdi Vasfi Marandi</name><name sortKey="Vasfi Marandi, Mehdi" sort="Vasfi Marandi, Mehdi" uniqKey="Vasfi Marandi M" first="Mehdi" last="Vasfi Marandi">Mehdi Vasfi Marandi</name><name sortKey="Vasfi Marandi, Mehdi" sort="Vasfi Marandi, Mehdi" uniqKey="Vasfi Marandi M" first="Mehdi" last="Vasfi Marandi">Mehdi Vasfi Marandi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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